Revi Mol Hai

acrjourna understanding of the anatomy and development of fetal and adult hair follicles and the molecular of the major embryonic pathways that regulate the hair follicle have led to exciting discoveries rning the development of basal cell carcinoma (BCC). These studies have shed light on the major f Sonic hedgehog (Shh) signaling and its interactions with the insulin-like growth factor (IGF) axis C development. New work, for example, explores a link between Shh signaling and IGF binding n-2 (IGFBP-2) in the hair follicle as it transforms into BCC. IGFBP-2 was overexpressed in specific llicle cells of mice with ectopically activated Shh signaling [keratin 14 (K14)-Cre: patched homo1 (Cre: Ptch1) mice]. Ptch1 deletion resulted in both an expansion of the stem cell niche and tion of cell differentiation. In transformed hair follicles, IGFBP-2 mediates epidermal progenitor inhibi cell expansion. Evidence also indicated that IGFBP-2 is expressed in human BCC. Cancer Prev Res; 3(10);